Culture is the most valuable asset of human society and an advanced and civilized society has read more avast and varied culture.Culture includes various and different values and abstract and/or materialentities, preserved with great care and transmitted from generation to generation.Nevertheless,whatever the historical period and the geographical
Costimulation with the recombinant SA-4-1BBL agonist of 4-1BB receptor on conventional CD4+ T cells (Tconvs) overcomes the suppression mediated by naturally occurring CD4+CD25+FoxP3+ T regulatory cells (Tregs).The mechanistic basis of this observation has remained largely unknown.Herein we show that Tconvs, but not Tregs, are the direct target of S
Alkaptonuria is a rare inborn read more error of metabolism with autosomal recessive inheritance with a mutation in homogentisate 1,2-dioxygenase.It results in accumulation of homogentisic acid in connective tissues (ochronosis).Most common ocular manifestations are bluish-black discoloration of the conjunctiva, cornea, and sclera.In this case repo